Evaluation of Correlation between D-dimer Levels with Disease Severity in Patients with Covid-19 Referred to Hamedan Besat Hospital in 2021-2022

Introduction: The Covid-19 virus affects the hemostasis system in infected people by causing thrombosis and it increases the level of D_dimer. This study was designed and conducted for the evaluation of correlation between D-dimer levels with disease severity in patients with Covid-19 referred to Hamedan Besat hospital. Methods and Materials: 366 patients with Covid-19 referred to Besat Hospital in Hamadan were randomly selected in this cross-sectional and retrospective study. The severity of the disease was assessed as level 1 that is the need for intensive care and level 2 which means the need for hospital care. The collected data were analyzed through Pearson correlation and independent t-test using SPSS software version 24. Results: The mean level of D-dimer in patients was 1.18 ± 1.01 microgram per milliliter. Disease severity was observed in 179 patients (47.3%) at level 1 and it was observed in 187 patients (52.7%) at level 2. Furthermore, the mean level of D-dimer in patients with level 1 was significantly higher than patients in level 2 (P value: 0.0001). There was a significant direct relationship between D-dimer level and hospitalization time and D-dimer level with ICU admission time (P value: 0.0001). Discussion and Conclusion: D-dimer level is more correlates with disease severity and it impacts on duration of hospitalization and ICU hospitalization.